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ea0029p701 | Diabetes | ICEECE2012

A Hydrophilic Derivative of Probucol, Probucol-(glutaric branched-triglycerol)₂ (ProBGL₂) Ameliorates Glucose Tolerance and Insulin Sensitivity by Independent Mechanism of the Canonical Potency of Probucol in HFD-fed mice.

Miyamoto L. , Kono M. , Nakagawa T. , Hattori H. , Ishizawa K. , Yoshimura Y. , Nemoto H. , Tsuchiya K.

Probucol is a traditional anti-hyperlipidemic agent harboring marked antioxidant activity. While probucol is highly hydrophobic, its succinic acid ester, succinobucol, was reported as a water-soluble derivative and was in clinical trials. Succinobucol was shown to be more potent in lipid-lowering, anti-inflammatory and anti-atherogenic effects than probucol in animal models. In addition, succinobucol reduced HbA1c in diabetic patients. Although the clinical trials finally ende...

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Endocrine Abstracts

A Hydrophilic Derivative of Probucol, Probucol-(glutaric branched-triglycerol)₂ (ProBGL₂) Ameliorates Glucose Tolerance and Insulin Sensitivity by Independent Mechanism of the Canonical Potency of Probucol in HFD-fed mice.

BiosciAbstracts

Endocrine Abstracts

A Hydrophilic Derivative of Probucol, Probucol-(glutaric branched-triglycerol)2 (ProBGL2) Ameliorates Glucose Tolerance and Insulin Sensitivity by Independent Mechanism of the Canonical Potency of Probucol in HFD-fed mice.

BiosciAbstracts

A Hydrophilic Derivative of Probucol, Probucol-(glutaric branched-triglycerol)₂ (ProBGL₂) Ameliorates Glucose Tolerance and Insulin Sensitivity by Independent Mechanism of the Canonical Potency of Probucol in HFD-fed mice.